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Kawasaki Disease

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Write 4 pages with APA style on Kawasaki Disease. In Kawasaki disease generalized vasculitis that is inflammation of all the vessels of the body is seen.the aneurysms are not only limitied to the coronary arteries but they may also affect other extraparenchymal muscular arteries such as celiac, mesenteric, femoral, renal, axillary and brachial arteries.there is edematous dissociation of the smooth muscle cells observed in the media of the affected vessels. Endothelial cell swelling and subendothelial edema are seen but the internal elastic lamina remains intact. An increased entry of neutrophills is found in the first 7 to 9 days and these rapidly change into large mononuclear cells together with the lymphocytes and IgA plasma cells. The internal elastic lamina becomes destroyed and eventually fibroblastic proliferation occurs. After this active inflammation over a period of months to week progressive fibrosis occurs alongwith scar formation. Coronary arteritis may also be seen in which there is intimal proliferation, neoangiogenesis, the intima is thickened and consists of linearly arranged micro vessels where there is normally presence of the smooth muscle cells and fibrous layers. In the lymph nodes thrombotic arteriolitis is seen and severe lymphadenitis with necrosis. In the first week the lymph nodes show abnormal hypesplasia of the endothelium of the postcapillary venule and hyperplasia of reticular cells around the postcapillary venule.There is no specific laboratory test for the diagnosis of Kawasaki disease. another problem faced is that immediately a doctor may not be able to know if the patient is suffering from Kawasaki disease or not. This is because the symptoms become very clear only after a week or so. To make sure that a child is suffering from Kawasaki’s disease it has been suggested that if fever along with conjunctivitis, strawberry tongue, peeling of the skin of palms of feet and hands and cracked lips is seen, doctors should start off with the treatment needed for a patient suffering from Kawasaki disease. at the same time certain tests which assist in finding out about the disease may also be performed. These tests include the electrocardiography and the echocardiography. A low cardiac output syndrome and shock may be seen due to poor myocardial function and in the electrocardiography arrhythmia, prolonged PR interval or non specific ST and T wave changes are observed.


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